Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation.
Identifieur interne : 008001 ( Main/Exploration ); précédent : 008000; suivant : 008002Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation.
Auteurs : Subash Babu [États-Unis] ; Carla P. Blauvelt ; V. Kumaraswami ; Thomas B. NutmanSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2005.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe (pharmacologie), Brugia malayi (immunologie), Cellules cultivées, Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (métabolisme), Filariose lymphatique (parasitologie), Glycoprotéines membranaires (antagonistes et inhibiteurs), Glycoprotéines membranaires (biosynthèse), Glycoprotéines membranaires (métabolisme), Glycoprotéines membranaires (physiologie), Humains, Interféron gamma (antagonistes et inhibiteurs), Interféron gamma (biosynthèse), Interleukine-5 (antagonistes et inhibiteurs), Interleukine-5 (biosynthèse), Lymphocytes B (immunologie), Lymphocytes B (métabolisme), Lymphocytes B (parasitologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD4+ (métabolisme), Lymphocytes T CD4+ (parasitologie), Monocytes (immunologie), Monocytes (métabolisme), Monocytes (parasitologie), Mâle, Protéines de liaison à l'ADN (antagonistes et inhibiteurs), Protéines de liaison à l'ADN (biosynthèse), Protéines de liaison à l'ADN (métabolisme), Récepteur de type Toll-1, Récepteur de type Toll-2, Récepteur de type Toll-4, Récepteur-9 de type Toll-like, Récepteurs de surface cellulaire (antagonistes et inhibiteurs), Récepteurs de surface cellulaire (biosynthèse), Récepteurs de surface cellulaire (métabolisme), Récepteurs de surface cellulaire (physiologie), Récepteurs de type Toll, Tuberculine (pharmacologie), Wuchereria bancrofti (immunologie).
- MESH :
- antagonistes et inhibiteurs : Glycoprotéines membranaires, Interféron gamma, Interleukine-5, Protéines de liaison à l'ADN, Récepteurs de surface cellulaire.
- biosynthèse : Glycoprotéines membranaires, Interféron gamma, Interleukine-5, Protéines de liaison à l'ADN, Récepteurs de surface cellulaire.
- immunologie : Activation des lymphocytes, Brugia malayi, Filariose lymphatique, Lymphocytes B, Lymphocytes T CD4+, Monocytes, Wuchereria bancrofti.
- métabolisme : Filariose lymphatique, Glycoprotéines membranaires, Lymphocytes B, Lymphocytes T CD4+, Monocytes, Protéines de liaison à l'ADN, Récepteurs de surface cellulaire.
- parasitologie : Filariose lymphatique, Lymphocytes B, Lymphocytes T CD4+, Monocytes.
- pharmacologie : Antigènes d'helminthe, Tuberculine.
- physiologie : Glycoprotéines membranaires, Récepteurs de surface cellulaire.
- Adulte, Adulte d'âge moyen, Animaux, Cellules cultivées, Femelle, Humains, Mâle, Récepteur de type Toll-1, Récepteur de type Toll-2, Récepteur de type Toll-4, Récepteur-9 de type Toll-like, Récepteurs de type Toll.
English descriptors
- KwdEn :
- Adult, Animals, Antigens, Helminth (pharmacology), B-Lymphocytes (immunology), B-Lymphocytes (metabolism), B-Lymphocytes (parasitology), Brugia malayi (immunology), CD4-Positive T-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (metabolism), CD4-Positive T-Lymphocytes (parasitology), Cells, Cultured, DNA-Binding Proteins (antagonists & inhibitors), DNA-Binding Proteins (biosynthesis), DNA-Binding Proteins (metabolism), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (metabolism), Elephantiasis, Filarial (parasitology), Female, Humans, Interferon-gamma (antagonists & inhibitors), Interferon-gamma (biosynthesis), Interleukin-5 (antagonists & inhibitors), Interleukin-5 (biosynthesis), Lymphocyte Activation (immunology), Male, Membrane Glycoproteins (antagonists & inhibitors), Membrane Glycoproteins (biosynthesis), Membrane Glycoproteins (metabolism), Membrane Glycoproteins (physiology), Middle Aged, Monocytes (immunology), Monocytes (metabolism), Monocytes (parasitology), Receptors, Cell Surface (antagonists & inhibitors), Receptors, Cell Surface (biosynthesis), Receptors, Cell Surface (metabolism), Receptors, Cell Surface (physiology), Toll-Like Receptor 1, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 9, Toll-Like Receptors, Tuberculin (pharmacology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , antagonists & inhibitors : DNA-Binding Proteins, Interferon-gamma, Interleukin-5, Membrane Glycoproteins, Receptors, Cell Surface.
- chemical , biosynthesis : DNA-Binding Proteins, Interferon-gamma, Interleukin-5, Membrane Glycoproteins, Receptors, Cell Surface.
- chemical , metabolism : DNA-Binding Proteins, Membrane Glycoproteins, Receptors, Cell Surface.
- chemical , pharmacology : Antigens, Helminth, Tuberculin.
- immunology : B-Lymphocytes, Brugia malayi, CD4-Positive T-Lymphocytes, Elephantiasis, Filarial, Lymphocyte Activation, Monocytes, Wuchereria bancrofti.
- metabolism : B-Lymphocytes, CD4-Positive T-Lymphocytes, Elephantiasis, Filarial, Monocytes.
- parasitology : B-Lymphocytes, CD4-Positive T-Lymphocytes, Elephantiasis, Filarial, Monocytes.
- chemical , physiology : Membrane Glycoproteins, Receptors, Cell Surface.
- Adult, Animals, Cells, Cultured, Female, Humans, Male, Middle Aged, Toll-Like Receptor 1, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 9, Toll-Like Receptors.
Abstract
Lymphatic filariasis is a disease characterized by immune dysregulation involving APC and T cell populations. To assess the contribution of TLR in mediating this dysregulation, we examined the expression of TLR1, TLR2, TLR4, and TLR9 on B cells and monocytes of filaria-infected and uninfected individuals. Baseline expression of TLR was significantly lower in B cells but not in monocytes of the filaria-infected group compared with the uninfected group. Upon stimulation with filarial Ag, a diminished up-regulation of TLR was observed in both B cells and monocytes of infected individuals. Finally, stimulation of B cells and monocytes with TLR ligands resulted in decreased B cell and monocyte activation/cytokine production, indicating a state of immune tolerance. This dysregulation is associated with diminished CD4(+) T cell production of IFN-gamma and IL-5. The diminished expression and function of TLR is thus a likely consequence of chronic Ag stimulation and could serve as a novel mechanism underlying the dysfunctional immune response in filariasis.
PubMed: 16002719
Affiliations:
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Blauvelt</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B" last="Nutman">Thomas B. 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Nutman</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Antigens, Helminth (pharmacology)</term><term>B-Lymphocytes (immunology)</term><term>B-Lymphocytes (metabolism)</term><term>B-Lymphocytes (parasitology)</term><term>Brugia malayi (immunology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD4-Positive T-Lymphocytes (metabolism)</term><term>CD4-Positive T-Lymphocytes (parasitology)</term><term>Cells, Cultured</term><term>DNA-Binding Proteins (antagonists & inhibitors)</term><term>DNA-Binding Proteins (biosynthesis)</term><term>DNA-Binding Proteins (metabolism)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (metabolism)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Humans</term><term>Interferon-gamma (antagonists & inhibitors)</term><term>Interferon-gamma (biosynthesis)</term><term>Interleukin-5 (antagonists & inhibitors)</term><term>Interleukin-5 (biosynthesis)</term><term>Lymphocyte Activation (immunology)</term><term>Male</term><term>Membrane Glycoproteins (antagonists & inhibitors)</term><term>Membrane Glycoproteins (biosynthesis)</term><term>Membrane Glycoproteins (metabolism)</term><term>Membrane Glycoproteins (physiology)</term><term>Middle Aged</term><term>Monocytes (immunology)</term><term>Monocytes (metabolism)</term><term>Monocytes (parasitology)</term><term>Receptors, Cell Surface (antagonists & inhibitors)</term><term>Receptors, Cell Surface (biosynthesis)</term><term>Receptors, Cell Surface (metabolism)</term><term>Receptors, Cell Surface (physiology)</term><term>Toll-Like Receptor 1</term><term>Toll-Like Receptor 2</term><term>Toll-Like 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(antagonistes et inhibiteurs)</term><term>Interleukine-5 (biosynthèse)</term><term>Lymphocytes B (immunologie)</term><term>Lymphocytes B (métabolisme)</term><term>Lymphocytes B (parasitologie)</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Lymphocytes T CD4+ (métabolisme)</term><term>Lymphocytes T CD4+ (parasitologie)</term><term>Monocytes (immunologie)</term><term>Monocytes (métabolisme)</term><term>Monocytes (parasitologie)</term><term>Mâle</term><term>Protéines de liaison à l'ADN (antagonistes et inhibiteurs)</term><term>Protéines de liaison à l'ADN (biosynthèse)</term><term>Protéines de liaison à l'ADN (métabolisme)</term><term>Récepteur de type Toll-1</term><term>Récepteur de type Toll-2</term><term>Récepteur de type Toll-4</term><term>Récepteur-9 de type Toll-like</term><term>Récepteurs de surface cellulaire (antagonistes et inhibiteurs)</term><term>Récepteurs de surface cellulaire (biosynthèse)</term><term>Récepteurs de surface cellulaire (métabolisme)</term><term>Récepteurs de surface cellulaire (physiologie)</term><term>Récepteurs de type Toll</term><term>Tuberculine (pharmacologie)</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>DNA-Binding Proteins</term><term>Interferon-gamma</term><term>Interleukin-5</term><term>Membrane Glycoproteins</term><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>DNA-Binding Proteins</term><term>Interferon-gamma</term><term>Interleukin-5</term><term>Membrane Glycoproteins</term><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA-Binding Proteins</term><term>Membrane Glycoproteins</term><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antigens, Helminth</term><term>Tuberculin</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Interféron gamma</term><term>Interleukine-5</term><term>Protéines de liaison à l'ADN</term><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Interféron gamma</term><term>Interleukine-5</term><term>Protéines de liaison à l'ADN</term><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term><term>Brugia malayi</term><term>Filariose lymphatique</term><term>Lymphocytes B</term><term>Lymphocytes T CD4+</term><term>Monocytes</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term><term>Brugia malayi</term><term>CD4-Positive T-Lymphocytes</term><term>Elephantiasis, Filarial</term><term>Lymphocyte Activation</term><term>Monocytes</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>B-Lymphocytes</term><term>CD4-Positive T-Lymphocytes</term><term>Elephantiasis, Filarial</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Filariose lymphatique</term><term>Glycoprotéines membranaires</term><term>Lymphocytes B</term><term>Lymphocytes T CD4+</term><term>Monocytes</term><term>Protéines de liaison à l'ADN</term><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphocytes B</term><term>Lymphocytes T CD4+</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>B-Lymphocytes</term><term>CD4-Positive T-Lymphocytes</term><term>Elephantiasis, Filarial</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Tuberculine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Membrane Glycoproteins</term><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Cells, Cultured</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Toll-Like Receptor 1</term><term>Toll-Like Receptor 2</term><term>Toll-Like Receptor 4</term><term>Toll-Like Receptor 9</term><term>Toll-Like Receptors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Cellules cultivées</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Récepteur de type Toll-1</term><term>Récepteur de type Toll-2</term><term>Récepteur de type Toll-4</term><term>Récepteur-9 de type Toll-like</term><term>Récepteurs de type Toll</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic filariasis is a disease characterized by immune dysregulation involving APC and T cell populations. To assess the contribution of TLR in mediating this dysregulation, we examined the expression of TLR1, TLR2, TLR4, and TLR9 on B cells and monocytes of filaria-infected and uninfected individuals. Baseline expression of TLR was significantly lower in B cells but not in monocytes of the filaria-infected group compared with the uninfected group. Upon stimulation with filarial Ag, a diminished up-regulation of TLR was observed in both B cells and monocytes of infected individuals. Finally, stimulation of B cells and monocytes with TLR ligands resulted in decreased B cell and monocyte activation/cytokine production, indicating a state of immune tolerance. This dysregulation is associated with diminished CD4(+) T cell production of IFN-gamma and IL-5. The diminished expression and function of TLR is thus a likely consequence of chronic Ag stimulation and could serve as a novel mechanism underlying the dysfunctional immune response in filariasis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Blauvelt, Carla P" sort="Blauvelt, Carla P" uniqKey="Blauvelt C" first="Carla P" last="Blauvelt">Carla P. Blauvelt</name><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B" last="Nutman">Thomas B. Nutman</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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